Agave
In short
Summary of findings for quick reference
Agave is a plant of the Americas, and its story is a Mesoamerican one. The genus has its centre of diversity in Mexico, where the maguey (Nahuatl metl) ranked among the most important plants of all. Residues in potsherds from Teotihuacan show pulque being made there between about 200 and 550 AD, and the Aztec and Nahua used leaf, sap, fermented sap and fibre for food, drink, cloth and medicine. An early written source is the Libellus de Medicinalibus Indorum Herbis of 1552, an early herbal written in the Americas, where pulque serves as the vehicle in several remedies. The plant reached Europe in the sixteenth century. Its early records belong to the Americas.
One plant, several very different products. The thick leaf is rich in steroidal saponins built on hecogenin and tigogenin, and in the twentieth century hecogenin from sisal agave was made into cortisone. The fresh leaf sap irritates the skin, loaded as it is with calcium oxalate crystals and saponins. The heart and sap give food and drink, namely roasted hearts, sweet aguamiel, fermented pulque and the commercial syrup, which is sugary, with fructose as its main sugar. Two small randomised trials found that a purified agave fructan, taken at 5 to 7.5 g a day, raised faecal bifidobacteria in healthy adults, and in a constipation trial without a placebo group there was no statistically significant difference between groups, leaving equivalence unproven. The anti-inflammatory and antibacterial leaf and sap findings described here come from laboratory and animal research. They provide no proof of an effect in people.
The EMA inventory checked on 9 October 2026 and the EU health claims register queried that day have no Agave entry. The one authorised inulin claim, that chicory inulin contributes to normal bowel function by increasing stool frequency at 12 g a day, belongs to native chicory inulin alone and carries over neither to agave inulin nor to agave syrup. Safety is rated caution because of the raw plant. Its fresh sap causes irritant contact dermatitis, in two reported cases with purpura and inflamed small blood vessels, both times after a chainsaw had sprayed sap onto the skin. Roasted hearts, aguamiel, pulque and the syrup are ordinary foods with the usual limits for alcohol and sugar. Anyone with hereditary fructose intolerance must avoid agave syrup and agave fructans altogether.
Clinical evidence ↔ Historical significanceWe display two separate evidence categories: clinical evidence from modern trials and historical significance from documented healing tradition. Both are valuable, but they answer different questions.Read more
In every encyclopedia entry we evaluate two distinct categories of evidence. Clinical evidence as used in trials meets a narrower but scientifically essential bar. At the same time, the hundreds of thousands of plant species worldwide have only partially been captured and tested in modern studies.
Alongside the trial picture our researchers compile a comprehensive overview of where and since when a plant has been used across different traditions of natural medicine. When a plant has been used as a medicinal plant in many cultures across many generations, that historical significance deserves to be visible too.
Our position: a truly informative overview emerges only when both categories sit side by side. We communicate transparently what counts as what.
Overview
Agave, Agave spp., is a genus of large rosette-forming succulents native to the Americas, with its centre of diversity in Mexico. Readers use the word agave for several related species: Agave americana, the century plant, Agave salmiana and Agave atrovirens, tapped for the sweet sap aguamiel and the fermented drink pulque, Agave tequilana, the blue agave behind tequila and much commercial agave syrup, and Southwest North American species such as Agave parryi. The plant is not a cactus but an asparagus relative, and this entry treats it at genus level because the different species share a saponin-rich leaf chemistry and overlapping traditional uses.
Agave is first a food, drink and fibre plant, and then a folk remedy. The Aztec maguey gave Mesoamerica roasted hearts to eat, the sweet sap aguamiel and fermented pulque to drink, and fibre for cord and cloth, while its sap, boiled down with salt, went onto wounds. Today agave is familiar through tequila and mezcal, sisal ropes and agave syrup, a sugary sweetener whose main sugar is fructose. The authorised bowel-function claim for chicory inulin does not cover this sweetener. Anyone cutting a living plant should know that its fresh leaf sap is a well-documented skin irritant.
History
The history of agave begins in the Americas. Hunters and gatherers in Mexico used the maguey thousands of years before writing, and for the Nahua, who called it metl, it was among the most important plants of all. It gave roasted hearts to eat, the sweet sap aguamiel and the fermented pulque, fibre for cord and cloth, and leaves that lather like soap. Myth has the first agave growing from the grave of the goddess Mayahuel, and pulque had gods of its own, the four hundred rabbits of drunkenness. Among the Aztecs pulque belonged to ritual, ordinary people could drink it only under strict rules, and drunkenness was severely punished.
Archaeology pushes pulque back well before the Aztecs. Researchers tested more than 300 potsherds from Teotihuacan for chemical traces of the bacterium Zymomonas mobilis, which ferments the sap, and showed that pulque was being kept in clay vessels there as early as 200 to 550 AD. An early written source is the Libellus de Medicinalibus Indorum Herbis of 1552, compiled from Nahua medical knowledge by Martín de la Cruz at the College of Santa Cruz in Tlatelolco and translated into Latin by Juan Badiano, an early herbal written in the Americas. Pulque, “our wine”, serves there as the vehicle for several remedies. The book describes reddish crystal ground in pulque and dropped into the eye, and an intervention for dropsy using bramble leaves, frankincense and pulque. These are historical recipes, not present-day treatment advice. Bernardino de Sahagún’s Florentine Codex, completed around 1577 with Nahua informants, takes the maguey, pulque and its gods into its great picture of Aztec life. For wounds Aztec healers used the sap itself, boiled down to a thick syrup and often mixed with salt, a remedy Mexican folk medicine still knows.
North of the Aztec world, agave fed the desert peoples of the American Southwest. The Apache, Comanche, Mohave and Paiute counted it among their most important foods. Crowns of Parry’s agave were baked in pits, the soft centres pounded into thin sheets and eaten, and the Mescalero Apache take their name from this mescal food. White Mountain Apache cooks stored pit-baked hearts for winter and fermented them into an intoxicating drink, the Navajo pressed juice from the baked fibres, and the fibre itself became rope, sandals, skirts and, among the Tohono O’odham, hairbrushes that doubled as combs.
Europe met the plant in the sixteenth century. The century plant was set out in the Mediterranean as an ornamental and above all as a hedge, especially in Spain, and has since gone wild in many warm regions. American dispensatories took it up in the nineteenth century. King’s American Dispensatory of 1898 and the US Dispensatory of 1918 record the fresh juice as laxative and diuretic and as a remedy for scurvy. King’s reports that the physician G. Perrin preferred it to lime juice and records his historical doses of up to two fluid ounces three times a day. King’s describes the leaf pulp as a counter-irritant that reddened the skin like mustard. In Mexico pulque became big business. A colonial ban ended in 1786, and after independence haciendas in Hidalgo and Tlaxcala sent it to the capital by rail. By the early twentieth century output reached about 500 million litres a year. The same century turned the leaf into a raw material. Hecogenin from sisal agave was made into cortisone, sisal fibre went into rope and cord, and in recent decades agave reached the shops as syrup and as a purified fibre supplement.
Mechanism
The chemistry of agave is dominated by steroidal saponins, and they connect the plant’s folk uses, its industrial role and its irritancy. The thick leaf is rich in spirostanol and furostanol saponins built on the sapogenins hecogenin and tigogenin, the same class of compounds that made agave and sisal an industrial source for the semisynthesis of steroid hormones in the twentieth century. Add calcium oxalate crystals in the leaf, and in the heart and sap the fructans called agavins, highly branched chains that differ in structure from the straight-chain inulin of chicory. The sweet sap, aguamiel, is fermented into pulque. Because the parts are chemically so different, the boiled sap, the fresh sap, the fibre and the syrup behave so differently.
The laboratory gives the traditional wound use a plausible basis. Boiled-down maguey sap held back pus-forming and gut bacteria in culture, and added salt strengthened its effect against Staphylococcus aureus. In mice, an acetone extract of Agave americana leaves reduced chemically induced ear swelling, and the saponin isolated from it, cantalasaponin-1, inhibited the swelling by up to 90 per cent. Reviews collect antimicrobial and antifungal findings for agave saponins. These studies do not establish wound healing in people. The same saponins, together with the calcium oxalate crystals, also explain why the fresh sap irritates the skin.
Human research on agave concerns its fructans, not the whole plant and not the syrup. Two small randomised, double-blind, placebo-controlled crossover trials tested purified agave fructan in healthy adults. In Reading, 38 volunteers took 5 g a day of a fructan from Agave tequilana for three weeks, and faecal bifidobacteria and lactobacilli rose compared with placebo, while short-chain fatty acids, secretory IgA and PGE2 did not change (Ramnani 2015). In Illinois, 29 adults took 5 or 7.5 g of agave inulin a day for three weeks. Bifidobacterium rose three- to fourfold and Desulfovibrio fell by 40 per cent (Holscher 2015).
A Mexico City trial followed 79 adults with functional constipation for eight weeks. They received 5 or 10 g of agave fructan a day, 5 g with 10 g maltodextrin, or 5 g psyllium with 10 g maltodextrin. About 70 per cent responded in each group, with no statistically significant difference between groups. There was no placebo group, and the finding leaves the treatments’ equivalence unproven (Coss-Adame 2024). In the Illinois trial’s tolerance analysis, 5 and 7.5 g of agave inulin a day slightly increased bloating and wind. At 7.5 g there was also slightly more abdominal pain and rumbling, with softer, more frequent stools. Diarrhoea did not increase statistically significantly compared with placebo (Holscher 2014).
The leaf and wound-sap findings discussed here come from laboratory and animal work. Leaf extracts and the saponin cantalasaponin-1 reduced ear swelling in mice, and boiled-down maguey sap inhibited bacteria in culture. These studies do not establish wound healing in people. Nor do the fructan trials establish a health benefit for agave syrup. In an analysis of 19 syrups, fructose made up on average about 84 per cent of the sugars. A low glycaemic index does not make it a health food.
Evidence
| Outcome | Class | Grade | Effect | Studies |
|---|---|---|---|---|
| Topical wound and skin care (traditional)Aztec healers dressed wounds with maguey sap boiled down to a syrup, often with salt, and Mexican folk medicine still knows the remedy. In the laboratory the syrup held back pus-forming and gut bacteria, and salt strengthened its effect on Staphylococcus aureus (Davidson and Ortiz de Montellano 1983). This laboratory work provides no proof of wound healing in people.Aztec and later Mexican folk use of boiled-down maguey sap on wounds | TraditionalTraditional use. Long-standing folk practice or EMA HMPC traditional-use monograph. | DEvidence quality grade D. Preliminary signal. A single small trial, pilot result, or laboratory or animal model. Clinical relevance unclear. This is an evidence rating, not a product endorsement. | Traditional topical use | |
| Prebiotic effect of isolated agave fructansRamnani 2015 (38 adults, 5 g a day for three weeks) and Holscher 2015 (29 adults, 5 or 7.5 g a day for three weeks) both found a statistically significant rise in faecal bifidobacteria. The findings concern a purified fibre supplement, not the plant or the syrup, and they are not an authorised claim.Healthy adults taking purified agave fructan (two small randomised trials, 38 and 29 people) | EmergingEmerging research. Early small trials suggest an effect but await replication. | CEvidence quality grade C. Mixed or limited evidence. Small trials, signals, or traditional use under an EMA HMPC traditional-use monograph. This is an evidence rating, not a product endorsement. | Two small trials, purified fructan | |
| Anti-inflammatory and antimicrobial activity of agave saponinsIn mice, acetone extracts of Agave americana leaves reduced chemically induced ear swelling, and the saponin isolated from them, cantalasaponin-1, inhibited it by up to 90 per cent (Monterrosas-Brisson 2013). Reviews collect antimicrobial findings from the laboratory. These are animal and laboratory results which do not establish an effect in people.In vitro and animal models (mouse ear oedema) | TraditionalTraditional use. Long-standing folk practice or EMA HMPC traditional-use monograph. | IEvidence quality grade I (Insufficient). Not enough evidence to draw a conclusion. More research needed. This is an evidence rating, not a product endorsement. | Preclinical only | |
| Agave syrup as a sweetener (metabolic note)Fructose makes up on average about 84 per cent of the sugars in agave syrup, which is why its glycaemic index is low. Fructose is still added sugar, so the low index is no health benefit, and there is no authorised claim. Like any sweetener, agave syrup is best used sparingly.General consumers using agave syrup as added sugar | InsufficientInsufficient data. No reliable trials or traditional sources available. | IEvidence quality grade I (Insufficient). Not enough evidence to draw a conclusion. More research needed. This is an evidence rating, not a product endorsement. | Not a health benefit |
The studies that matter.
In a randomised, double-blind, placebo-controlled crossover trial in Illinois, 29 healthy adults took 0, 5 or 7.5 g of agave inulin a day for three weeks each. Bifidobacterium in the stool rose three- to fourfold and Desulfovibrio fell by 40 per cent, both statistically significant. A small, well-designed trial that shows a clear shift in gut bacteria, though not yet a health benefit.
Holscher HD, Bauer LL, Gourineni V, Pelkman CL, Fahey GC Jr, Swanson KS. Holscher HD, Bauer LL, Gourineni V, Pelkman CL, Fahey GC Jr, Swanson KS. Agave inulin supplementation affects the fecal microbiota of healthy adults participating in a randomized, double-blind, placebo-controlled, crossover trial. J Nutr. 2015;145(9):2025-2032. doi:10.3945/jn.115.217331 doi:10.3945/jn.115.217331In Reading, 38 healthy adults took 5 g a day of a purified fructan from Agave tequilana or a maltodextrin placebo, three weeks each, in a double-blind crossover trial. Faecal bifidobacteria and lactobacilli rose statistically significantly, while short-chain fatty acids and immune markers did not change. A small trial with a co-author from a Mexican food company, whose result the Illinois trial confirms.
Ramnani P, Costabile A, Bustillo AG, Gibson GR. Ramnani P, Costabile A, Bustillo AG, Gibson GR. A randomised, double-blind, cross-over study investigating the prebiotic effect of agave fructans in healthy human subjects. J Nutr Sci. 2015;4:e10. doi:10.1017/jns.2014.68 doi:10.1017/jns.2014.68In Mexico City, 79 adults with functional constipation received 5 or 10 g of agave fructan a day, 5 g with 10 g maltodextrin, or 5 g psyllium with 10 g maltodextrin for eight weeks in a randomised, double-blind trial. About 70 per cent responded in every group, with no statistically significant difference, and stool frequency, consistency and quality of life improved in all groups. Without placebo, the fibre’s contribution to the improvement cannot be determined, and equivalence remains unproven despite the lack of a group difference. As in the Reading trial, one co-author was affiliated with a Mexican food company.
Coss-Adame E, García-Cedillo MF, Bustillo-Armendáriz G, et al. Coss-Adame E, García-Cedillo MF, Bustillo-Armendáriz G, Huerta-de la Torre MF, Delgado-Bautista MK, Arenas-Martinez J, Cassis-Nosthas L. Agave tequilana fructans versus Psyllium plantago for functional constipation: randomized double-blind clinical trial. J Clin Gastroenterol. 2024;58(5):475-482. doi:10.1097/MCG.0000000000001888 doi:10.1097/MCG.0000000000001888J. R. Davidson and Bernard Ortiz de Montellano tested the Aztec wound remedy of concentrated maguey sap in the laboratory. The syrup inhibited pus-forming and gut bacteria, and salt, as tradition prescribed, strengthened its effect against Staphylococcus aureus. Laboratory findings only, but they give the old practice a plausible basis.
Davidson JR, Ortiz de Montellano BR. Davidson JR, Ortiz de Montellano BR. The antibacterial properties of an Aztec wound remedy. J Ethnopharmacol. 1983;8(2):149-161. doi:10.1016/0378-8741(83)90051-x doi:10.1016/0378-8741(83)90051-xA case report from Texas describes purpura, bleeding into the skin, after contact with agave sap in an otherwise healthy patient, with tissue findings of an evolving leukocytoclastic vasculitis. The sap contains calcium oxalate crystals, acrid oils and saponins, all known irritants. A single case, which together with a second published case carries the caution rating for handling the raw plant.
Ricks MR, Vogel PS, Elston DM, Hivnor C. Ricks MR, Vogel PS, Elston DM, Hivnor C. Purpuric agave dermatitis. J Am Acad Dermatol. 1999;40(2 Pt 2):356-358. doi:10.1016/s0190-9622(99)70485-8 doi:10.1016/s0190-9622(99)70485-8
Usage
Forms and preparation
Agave is not a tea herb. The heart is roasted for food, and the sap is tapped. Fresh, it is called aguamiel, and it ferments into milky pulque. Mezcal and tequila are distilled from cooked hearts after fermentation. For wounds the Aztecs boiled the sap down to a syrup, often with salt, a historical use rather than a recommendation for wound treatment. Fresh leaf sap irritates the skin. The leaf fibre is stripped out and spun into sisal and other cordage. Pulque making is a craft of its own. The tlachiquero picks a maguey of six to fifteen years that is about to flower, cuts out the flower bud and the central leaves and leaves a hollow in the heart. He scrapes its walls so that sap keeps welling up and draws it off twice a day, at dawn and at dusk, by suction through a long dried gourd, the acocote. A plant gives four to six litres a day for three to six months, around 1,000 litres in all, and then dies. A little finished pulque, the seed, starts each new batch in the vats of the tinacal, and the result is a milky, slightly sour drink with 4 to 7 per cent alcohol. In the shops agave appears as agave syrup, made by breaking the plant’s fructans down into mostly fructose, as purified agave fructans or agave inulin sold as a fibre supplement, and as agave fibre. These are processed products with little in common with the raw plant. If you grow agave or cut its leaves, wear gloves and keep the sap off your skin.
Dosage
The studies discussed here do not establish a generally recommended medicinal dose. Agave syrup is a sweetener and, like any added sugar, best used sparingly. Purified agave fructans have been tested at 5 to 7.5 g a day in healthy adults and at up to 10 g a day in constipation. These are study amounts, and supplements should be taken as their label says. The raw leaf and fresh leaf sap are not for eating. If you have a medical condition or take medicines, ask a doctor or pharmacist before starting a fructan supplement.
Special populations
Pulque contains alcohol and is not for children or for pregnancy. Avoiding it is also the safest choice when breastfeeding. Agave syrup is sugary, with fructose as its main sugar. Anyone watching their sugar should keep the amount small, and people with hereditary fructose intolerance must avoid both the syrup and agave fructan products. The adult trials discussed here do not establish the safety of concentrated fructan supplements in pregnancy, breastfeeding or childhood. Take medical advice first. Keep children away from the sharp leaves and fresh leaf sap.
Safety
Drug interactions
Pulque contains alcohol, so alcohol’s interactions with medicines apply. The fructan trials discussed here did not specifically investigate interactions with medicines. If you take medicines, have a doctor or pharmacist check a fructan supplement before you start it. They can also advise whether the doses need to be spaced apart.
Contraindications
Contraindications still depend on the individual food or product. The absence of an Agave monograph from the EMA inventory checked on 9 October 2026 does not make every agave product safe. Known hypersensitivity to agave or contact allergy: avoid the plant and its sap. Hereditary fructose intolerance: avoid agave syrup and agave fructan products completely. Fructose malabsorption or a need to limit fructose: agave syrup is sugary, with fructose as its main sugar. Avoid it or strictly limit the amount. Pregnancy, breastfeeding and children: alcoholic pulque is not suitable, and concentrated agave supplements have only a small safety record, so seek advice.
Side effects
For the foods, the points to watch are sugar and alcohol. Agave syrup is sugary, its main sugar is fructose, and pulque contains alcohol. Fresh leaf sap can cause irritant contact dermatitis, including purpura in published cases, and the leaf spines cause puncture wounds. In the Illinois trial, 5 and 7.5 g of agave inulin a day slightly increased bloating and wind, and at 7.5 g there was also slightly more abdominal pain and rumbling, with softer, more frequent stools. Diarrhoea did not increase statistically significantly compared with placebo. In Reading, mild to moderate bloating and some severe wind were reported at 5 g a day. Allergic sensitisation to the sap has been reported in a gardener. If a reaction appears, stop and seek advice.
Look-alikes
Similar plants and look-alikes
Aloe vera (Aloe vera)
Aloe vera can be confused with agave, because both are large, fleshy, spiny rosette succulents. They are not closely related. Aloe is an Old World plant from Arabia and Africa with a soft inner leaf gel that is a familiar skincare ingredient, while agave is a New World plant whose fresh sap is an irritant and whose leaf is fibrous and saponin-rich. The two should not be treated as interchangeable. Aloe leaf gel is used on skin. Raw agave sap is not.
Agave syrup versus the raw agave plant
These are not the same thing. Agave syrup is a processed, concentrated sweetener made by breaking the plant’s fructans down into mostly fructose, on average about 84 per cent of its sugars. It is used like other added sugar. The raw agave leaf and its fresh sap are something else, for the sap irritates the skin and the raw plant is not food. What holds for the syrup or for purified fructans says nothing about the raw plant, and the irritant sap says nothing about the syrup.
FAQs
Is agave a cactus, and what is it used for?
No. Agave is a large rosette succulent of the asparagus family, native to the Americas, and in Mexico it is called maguey. People eat its roasted hearts, drink its sweet sap fresh as aguamiel or fermented as pulque, distil tequila and mezcal from it, spin its leaf fibre into sisal and turn its sap into agave syrup. Aztec healers also put it on wounds, but it was always a food and fibre plant first.
Is agave approved by the European regulator for any health use?
The historical uses and small fructan trials do not establish a medicinal authorisation. The EMA inventory checked on 9 October 2026 has no Agave entry, nor does the EU health claims register queried that day. The authorised bowel-function claim for native chicory inulin covers the chicory ingredient defined in the regulation. It cannot be transferred to agave fibre or agave syrup.
Is agave syrup a healthy sweetener?
No healthier than other sugars. Fructose makes up on average about 84 per cent of the sugars in agave syrup, and that is why its glycaemic index is low, because fructose raises blood sugar far less than glucose does. A low glycaemic index alone does not make a sweetener healthy, though, and no health claim is authorised for agave syrup. Treat it like any added sugar and use it sparingly. People with hereditary fructose intolerance must avoid it completely.
Is the agave plant safe to handle?
Only with gloves. The leaves end in hard spines, and the fresh sap is a documented skin irritant full of calcium oxalate crystals and saponins. It usually causes a rash of small bumps and blisters, and in two reported cases, both after a chainsaw had sprayed sap onto the skin, it also caused purpura from inflamed small blood vessels. Wear gloves and long sleeves when you cut agave, keep the sap off your skin and away from your eyes, use hand tools rather than a chainsaw, and do not eat the raw leaf or fresh sap.
How old is the tradition of agave?
Thousands of years old in Mexico, but young in Europe. Hunters and gatherers used the maguey long before writing, and residues in potsherds show pulque being made at Teotihuacan around 200 to 550 AD. An early written source is the Libellus of 1552, an early herbal of the Americas, followed by Sahagún’s Florentine Codex. The plant reached Europe in the sixteenth century. The early records of its use belong to the Americas.
Does the century plant really take a hundred years to flower?
No, the name comes from an old misconception. Flowering age depends on species and growing conditions. For Agave americana, King’s American Dispensatory records about ten years in its native climate and a flower stalk of six to twelve metres. The flowering rosette then dies. Selected maguey plants of six to fifteen years are tapped for pulque. The tlachiquero removes the flower bud before it produces a stalk and collects the sap instead.
Why is agave connected to steroid hormones?
Agaves contain steroidal saponins, including compounds based on hecogenin and tigogenin. In the twentieth century, hecogenin from sisal agave was used as a starting material for cortisone. That required industrial chemical processing. This history as a raw material does not mean that pulque or agave syrup supplies cortisone.
24 sources.
- Ricks MR, Vogel PS, Elston DM, Hivnor C. Ricks MR, Vogel PS, Elston DM, Hivnor C. Purpuric agave dermatitis. J Am Acad Dermatol. 1999;40(2 Pt 2):356-358. doi:10.1016/s0190-9622(99)70485-8. 1999. doi:10.1016/s0190-9622(99)70485-8
- Cherpelis BS, Fenske NA. Cherpelis BS, Fenske NA. Purpuric irritant contact dermatitis induced by Agave americana. Cutis. 2000;66(4):287-288. 2000. PMID:11109152
- Fazli FR. Fazli FR. Contraceptives and other steroid drugs: their production from steroidal sapogenins. Pak J Sci. 1968;20(1-2):64-67. 1968. PMID:12229321
- Willems JL, Low NH. Willems JL, Low NH. Major carbohydrate, polyol, and oligosaccharide profiles of agave syrup. Application of this data to authenticity analysis. J Agric Food Chem. 2012;60(35):8745-8754. doi:10.1021/jf3027342. 2012. doi:10.1021/jf3027342
- Monterrosas-Brisson N, Ocampo ML, Jiménez-Ferrer E, et al.. Monterrosas-Brisson N, Ocampo ML, Jiménez-Ferrer E, Jiménez-Aparicio AR, Zamilpa A, Gonzalez-Cortazar M, Tortoriello J, Herrera-Ruiz M. Anti-inflammatory activity of different agave plants and the compound cantalasaponin-1. Molecules. 2013;18(7):8136-8146. doi:10.3390/molecules18078136. 2013. doi:10.3390/molecules18078136
- Holscher HD, Doligale JL, Bauer LL, Gourineni V, Pelkman CL, Fahey GC, Swanson KS. Holscher HD, Doligale JL, Bauer LL, Gourineni V, Pelkman CL, Fahey GC, Swanson KS. Gastrointestinal tolerance and utilization of agave inulin by healthy adults. Food Funct. 2014;5(6):1142-1149. doi:10.1039/c3fo60666j. 2014. doi:10.1039/c3fo60666j
- Ramnani P, Costabile A, Bustillo AG, Gibson GR. Ramnani P, Costabile A, Bustillo AG, Gibson GR. A randomised, double-blind, cross-over study investigating the prebiotic effect of agave fructans in healthy human subjects. J Nutr Sci. 2015;4:e10. doi:10.1017/jns.2014.68. 2015. doi:10.1017/jns.2014.68
- Holscher HD, Bauer LL, Gourineni V, Pelkman CL, Fahey GC Jr, Swanson KS. Holscher HD, Bauer LL, Gourineni V, Pelkman CL, Fahey GC Jr, Swanson KS. Agave inulin supplementation affects the fecal microbiota of healthy adults participating in a randomized, double-blind, placebo-controlled, crossover trial. J Nutr. 2015;145(9):2025-2032. doi:10.3945/jn.115.217331. 2015. doi:10.3945/jn.115.217331
- Gaughan S, Ayres L, Baker PR II. Gaughan S, Ayres L, Baker PR II. Hereditary fructose intolerance. In: Adam MP et al., eds. GeneReviews. Seattle (WA): University of Washington, Seattle; 2015, updated 2021. 2021. PMID:26677512
- Sidana J, Singh B, Sharma OP. Sidana J, Singh B, Sharma OP. Saponins of Agave: chemistry and bioactivity. Phytochemistry. 2016;130:22-46. doi:10.1016/j.phytochem.2016.06.010. 2016. doi:10.1016/j.phytochem.2016.06.010
- Escalante A, López Soto DR, Velázquez Gutiérrez JE, Giles-Gómez M, Bolívar F, López-Munguía A. Escalante A, López Soto DR, Velázquez Gutiérrez JE, Giles-Gómez M, Bolívar F, López-Munguía A. Pulque, a traditional Mexican alcoholic fermented beverage: historical, microbiological, and technical aspects. Front Microbiol. 2016;7:1026. doi:10.3389/fmicb.2016.01026. 2016. doi:10.3389/fmicb.2016.01026
- Gómez Torrijos E, Gratacós Gómez AR, Gonzalez Jimenez O, et al.. Gómez Torrijos E, Gratacós Gómez AR, Gonzalez Jimenez O, Joyanes Romo JB, Cañas AP, Garcia Rodriguez R. Allergic sensitization to the irritant sap of the variegated century plant in a gardener. Contact Dermatitis. 2021;84(3):196-197. doi:10.1111/cod.13702. 2021. doi:10.1111/cod.13702
- Coss-Adame E, García-Cedillo MF, Bustillo-Armendáriz G, et al.. Coss-Adame E, García-Cedillo MF, Bustillo-Armendáriz G, Huerta-de la Torre MF, Delgado-Bautista MK, Arenas-Martinez J, Cassis-Nosthas L. Agave tequilana fructans versus Psyllium plantago for functional constipation: randomized double-blind clinical trial. J Clin Gastroenterol. 2024;58(5):475-482. doi:10.1097/MCG.0000000000001888. 2024. doi:10.1097/MCG.0000000000001888
- Davidson JR, Ortiz de Montellano BR. Davidson JR, Ortiz de Montellano BR. The antibacterial properties of an Aztec wound remedy. J Ethnopharmacol. 1983;8(2):149-161. doi:10.1016/0378-8741(83)90051-x. 1983. doi:10.1016/0378-8741(83)90051-x
- Moerman DE; Botanical Research Institute of Texas. Moerman DE. Native American Ethnobotany Database, Botanical Research Institute of Texas: search results for Agave (147 recorded uses). 2025. Source
- European Commission. Commission Regulation (EU) 2015/2314 of 7 December 2015 authorising a health claim made on foods, other than those referring to the reduction of disease risk and to children's development and health, and amending Regulation (EU) No 432/2012 (native chicory inulin). 2015. Source
- Remington JP, Wood HC, et al.. Remington JP, Wood HC, et al., eds. The Dispensatory of the United States of America. 20th ed. Philadelphia: Lippincott; 1918. Agave. 1918. Source
- Martín de la Cruz, Juan Badiano; translated by William Gates. De la Cruz M, Badiano J. The De la Cruz-Badiano Aztec Herbal of 1552 (Libellus de Medicinalibus Indorum Herbis). Translated by William Gates. Baltimore: The Maya Society, Publication No. 22; 1939. 1939. Source
- Felter HW, Lloyd JU. Felter HW, Lloyd JU. King's American Dispensatory. 18th ed., 3rd revision. Cincinnati: Ohio Valley Co.; 1898. Agave virginica, related species Agave americana. 1898. Source
- European Medicines Agency. EMA herbal medicines register, current official export. 2026. Source
- European Commission. European Commission. EU Register of nutrition and health claims.. Source
- Holt TE, Clayton JC. Holt TE, Clayton JC. Process for purification of hecogenin. US2827456A. 18 March 1958. 1958. Source
- National Institute on Alcohol Abuse and Alcoholism. Harmful interactions: mixing alcohol with medicines. Source
- Mescalero Apache Tribe. Our culture. Source
Legal notice: The depiction of historical significance and traditional use is context within our encyclopedia and not a health claim for any product, not a treatment promise, and not a substitute for medical advice. What may be stated on product labels, product pages, or in advertising is governed by the applicable legal requirements.